![]() "gc.log" will contain the information about the collections, if you see a lot of gc activity (mostly FULL GC) when the issue occurs, then you would need to tune your memory/gc settings. verbose:gc -XX:+PrintGCDetails -XX:+PrintGCDateStamps -Xloggc:\gc.log You can try adding below JAVA options in your "run.bat" to analyse what's wrong with GC : I'm going to up the memory anyway, but what clues do we look for to determine if there is a leak and/or better GC settings? Should we be doing something more specific? And if the GC keeps running that often even after the thread to do the nightly job has ended, do I have a memory leak somewhere? We do sometimes run out of memory, but maybe it needs Xmx of 4gb just to finish the job. Xrs -Xms256M -Xmx2048M -XX:MaxPermSize=256m -XX:+CMSClassUnloadingEnabled -XX:+UseConcMarkSweepGC Using mostly a default run.bat, I have the jvm args set to: This happens every 5 seconds or so, probably GC? The process gets to 2.5GB and never goes down, but I hear that's normal with heap space? But after a few days of this, I begin to see the cpu spike to 100% of one cpu for a few seconds, then go down. At night, it runs a large job and gobbles memory. Read more about how to correctly acknowledge RSC content.I have a jboss 5.1 app with sun jdk 1.7.something. Permission is not required) please go to the Copyright If you want to reproduce the wholeĪrticle in a third-party commercial publication (excluding your thesis/dissertation for which If you are the author of this article, you do not need to request permission to reproduce figuresĪnd diagrams provided correct acknowledgement is given. Provided correct acknowledgement is given. If you are an author contributing to an RSC publication, you do not need to request permission Please go to the Copyright Clearance Center request page. They offer installation by their skilled technicians and have a large stock of performance. To request permission to reproduce material from this article in a commercial publication, Spike, their tuner, is a skilled auto mechanic with a long history. Provided that the correct acknowledgement is given and it is not used for commercial purposes. This article in other publications, without requesting further permission from the RSC, My Orion Website & Server is very slow / CPU & Memory Spike /Polling gaps what. Fadda,Ĭreative Commons Attribution-NonCommercial 3.0 Unported Licence. Performance Monitor (NPM) Product Forums Network Performance Monitor (NPM). ![]() We discuss how the absence of the N370 glycan in the SARS-CoV-2 S frees the RBD glycan binding cleft, which becomes available to bind cell-surface glycans, and potentially increases host cell surface localization.įine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 SĪ. Furthermore, our results suggest that the loss of glycosylation at N370, a newly acquired modification in the SARS-CoV-2 S glycan shield's topology, may have contributed to increase the SARS-CoV-2 infectivity as we find that N-glycosylation at N370 stabilizes the closed RBD conformation by binding a specific cleft on the RBD surface. Our results from multi-microsecond molecular dynamics simulations indicate that the type of glycosylation at N234, N165 and N343 greatly affects the stability of the receptor binding domain (RBD) open conformation, and thus its exposure and accessibility. ![]() Moreover, the functional role of the glycan shield in the SARS-CoV-2 pathogenesis suggests that the evolution of the sites of glycosylation is potentially intertwined with the evolution of the protein sequence to affect optimal activity. Recent studies indicate that the occupancy and structures of the SARS-CoV-2 S glycans depend not only on the nature of the host cell, but also on the structural stability of the trimer a point that raises important questions about the relative competence of different glycoforms. When your system is at risk of spike events, the team must run a spikes test and tune the system several times. The dense glycan shield is an essential feature of the SARS-CoV-2 spike (S) architecture, key to immune evasion and to the activation of the prefusion conformation.
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